) didn't attain genome-wide significance just after adjustment. Because the result dimensions remain mainly unchanged when modified for BMI, the statistical importance on the associations was diluted by the reduction in sample size.
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Apparently, CHEK2 also performs a crucial function in foetal oocyte attrition, a phenomenon through which eighty% of your Original ovarian oocyte reserve is lost for the here duration of foetal progress in mammals (Tharp et al.
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We also analyzed if conditioning the discovery GWAS success with I157T and validation GWAS with c.1100delC would have an impact on the significance with the direct variants. Conditioning the invention analysis on I157T had a minimal effect on the genome-large considerable associations During this locus, using a P